Angelina Jolie’s Journey as a Previvor and Advocate for Genetic Testing

Actress Angelina Jolie, known for her beauty and talent, has also become a symbol of strength and resilience in the face of cancer.

Fourteen years ago, Jolie tragically lost her mother to ovarian cancer.

Little did she know that she would soon discover she carried a genetic mutation known as BRCA1, which significantly increased her risk of developing bre-st or ovarian cancer.

This revelation led her on a path towards becoming a previvor, inspiring countless women around the world.

In 2013, Jolie made headlines when she underwent a preventive double mastectomy to reduce her risk of bre-st cancer.

This brave decision not only protected her own health but also sparked a global conversation about genetics and cancer prevention.

Women everywhere found solace in Jolie's story, realizing that if someone as iconic as her could take such drastic measures, they too could consider their options.

Two years later, Jolie made yet another difficult choice by undergoing a preventive oophorectomy, the removal of her ovaries.

By sharing her experiences through an op-ed in The New York Times and subsequent open letters, she shed light on her journey as a previvor, giving hope to women facing similar decisions and emotional struggles.

Jolie's mother, Marcheline Bertrand, was an actress and activist who unfortunately never had the chance to meet all of her grandchildren.

Her untimely death from cancer paved the way for Jolie to make a difference in the lives of millions of women worldwide.

Reflecting on her loss, Jolie expressed the profound impact her mother's absence had on her own life, likening it to having a protective blanket ripped away.

Inspired by her mother's legacy, Jolie has become a passionate advocate for various causes, particularly humanitarian work with the United Nations High Commissioner for Refugees (UNHCR).

Through her work, she has learned invaluable lessons about family, resilience, dignity, and survival from refugees who have endured war and persecution.

The BRCA mutation, also known as B-R-C-A or Brah-kuh, plays a crucial role in Jolie's story.

GYN oncologist Dr. Rebecca Arend explains that individuals with this mutation are unable to repair DNA breaks, making them more susceptible to certain types of cancer.

It is essential for those with BRCA mutations, especially women already diagnosed with bre-st cancer, to undergo regular monitoring.

Some may choose to follow Jolie's lead and opt for preventive surgeries, a decision that may be recommended by their doctors depending on the specific circumstances.

Genetic testing is a vital tool in identifying the presence of BRCA mutations and assessing the risk of developing ovarian cancer.

Dr. Beth Karlan from UCLA Medical Center emphasizes the importance of discussing genetic testing with healthcare professionals, as it can provide life-saving information and guide individuals towards appropriate screenings and preventive measures.

It is worth noting that the risk of inheriting BRCA mutations is equal from both parents.

If someone tests positive for these mutations, their blood relatives have a 50/50 chance of carrying them as well.

This knowledge underscores the significance of genetic testing in families affected by cancer.

Angelina Jolie's journey as a previvor and advocate for genetic testing has inspired countless women to take charge of their health.

Her bravery and openness have ignited conversations about the importance of early detection, preventive measures, and the power of knowledge.

By sharing her story, Jolie continues to make a lasting impact on the lives of women around the world, ensuring that her mother's legacy lives on through the chance for others to potentially meet their grandchildren and cherish precious moments with their loved ones.